10th Meeting

of the

European Epidermal Barrier Research Network



COST Action BM0903:
Skin Barrier in Atopic Disease


19 and 20 September, 2012


Venice (Italy)


Scientific Organising Committee:
Olga Lopez (Barcelona), Marek Haftek (Lyon)

Correspondence: barrier.venice@gmail.com

Websites: E2BRN and SkinBAD

The meeting will take place at the site of the main ESDR congress:
Palazzo del Casinò, Venice Lido Congress Centre

Venice Convention

Welcome to ESDR 2010

Those who register for the ESDR meeting
(ESDR members: EUR 330, non ESDR members: EUR 600)
are automatically registered for the E2BRN meeting at no additional costs.
One can also register on-site for the E2BRN meeting only, at the reduced fee of EUR 100.

Scientific Program of the 10th E2BRN meeting - pdf (60kb)

Scientific Program

Wednesday, September 19

13:30 - 16:20

Session 1 (Chairperson: M. Haftek)

13:30 - 14:00
INVITED lecture 1
Leopold Eckhart (Vienna, Austria):

Comparative genomics of the epidermal barrier

14:00 - 14:50

Short communications (10min. + 2min. discussion):

  • PKCs are involved in RIPK4-dependent signalling pathways,
    C. Rösselet, P. De Groote, G. Tanghe, B. Gilbert, P. Vandenabeele, S. Lippens, W. Declercq,
    Ghent University, Belgium.
    Poster 10 (P10)

  • Inhibition of kallikrein-related peptidases by protease Inhibitors in Man and Mouse: the same, the same but not the same,
    J. Fischer, Y. Koblyakova, B. Spudy, S. Jung, Z. Wu, J. Grötzinger, U. Meyer-Hoffert,
    University Hospital Schleswig-Holstein, Kiel, Germany.

  • Human skin explants: a model to study the interaction between epidermal cells and the cutaneous microbiota,
    G. Percoco
    , Y. Ramdani, M. Bénard, C. Merle, T. Jaouen, E. Lati, M. Feuilloley, L. Lefeuvre, A. Driouich, ML. Follet-Gueye,
    Univ. of Caen & Uriage Labs., France.

  • Role of fibroblasts in the pathogenesis of atopic dermatitis,
    A. Berroth,
    J. Kühnl, N. Kurschat, A. Schwarz,F. Stäb, T. Schwarz, H. Wenck, R. Fölster-Holst , G. Neufang,
    Hamburg & Kiel, Germany.

14:50 - 15:20

INVITED lecture 2
Katerina Vavrova (Praha, Czech Rep.):
Ceramides in the skin barrier: length matters

15:20 - 16:20

Short communications (10min. + 2min. discussion):
  • Impaired skin barrier function in atopic eczema correlates with altered stratum corneum lipid organization,
    M. Janssens,
    J. van Smeden, G.S. Gooris, W. Bras, G. Portale, P.J. Caspers, S. Kezic, A.P.M. Lavrijsen, J.A. Bouwstra.
    Leiden & Amsterdam, The Netherlands.

  • Bicosome technology: an advanced biocompatible delivery system for skin care and treatment,
    L. Barbosa-Barros
    , G. Rodríguez, M. Cócera, A. De la Maza, O. López, Smartnano-CSIC,
    Barcelona, Spain.

  • Disturbed lipid metabolism in foetal skin predisposes for development of allergic disorders,
    D. Khnykin
    , D. Crumrine, MH. Lin, Y. Uchida, J. Miner, P. Elias, F. Jahnsen, Oslo, Norway, SF & St. Louis, USA.

  • Skin barrier function efficacy of ceramide containing formulations,
    C. Barba
    , A. Semenzato, G. Baratto, J.L. Parra, L. Coderch,
    IQAC-CSIC, Barcelona, Spain.

  • Intravenous lipid emulsions influence epidermal barrier function,
    A. Lajoine
    , P. Gelas , D. Salmon, C. Bergoin, L. Roussel , F. Falson , M. Haftek, C. Pivot, F. Pirot,
    University Lyon 1, France.

16:20 - 17:20

Coffee + Posters

17:20 - 18:50

Session 2 (Chairperson: J. Brandner)

17:20 - 17:50
INVITED lecture 3
Sara J. Brown (Dundee and Dublin, UK & IR):
Genotype-phenotype correlations in atopic dermatitis

17:50 - 18:50
Short communications (10min. + 2min. discussion):
  • FLG mutations and risk for hand eczema and contact dermatitis,
    S. Kezic, J.P. Thyssen
    Amsterdam, The Netherlands & Copenhagen, Denmark.

  • Reduced expression of filaggrin-like proteins in the lesional and non-lesional skin of atopic dermatitis patients,
    L. Pellerin
    , J. Henry, S. Balica, C. Jean-Decoster, B. Hansmann, AM. Schmitt, G. Serre, C. Paul, M. Simon,
    CNRS; INSERM; Pierre Fabre Labs. & University of Toulouse, France. (P20)

  • Differential expression pattern of hyaluronan synthases during normal human keratinocyte differentiation and in lesional epidermis from atopic dermatitis,
    J. Malaisse
    , A. Nikkels, B. Flamion, Y. Poumay,
    Namur & Liège, Belgium.

  • Histamine interferes with keratinocyte differentiation and the formation of the epidermal barrier,
    M. Gschwandtner, M. Mildner, V. Mlitz, L. Eckhart, T. Werfel, R. Gutzmer, P.M. Elias, E. Tschachler,
    Vienna, Austria; Hannover, Germany; SF, USA & Neuilly, France.

  • System-level investigation of risk factor for atopic dermatitis by mathematical modelling and analysis,
    E. Domínguez-Hüttinger, M. Ono, RJ. Tanaka,
    London, UK.

Networks’ dinner (location and price to be announced)
Thursday, September 20

09:00 - 10:30 Session 3 (Chairperson: O. López)

09:00 - 09:30
Invited lecture 4
Annett Schroeter (Halle, Germany):
New insights into the nanostructure of stratum corneum lipid model membrane derived by neutron diffraction investigations

09:30 - 10:30
Short communications (10min. + 2min. discussion):
  • Mass Spectrometry Imaging: New Tools for Healthcare Research,
    M.R. Clench,

    Sheffield Hallam University, UK.

  • Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes: no direct effect of claudin-1 on water barrier,
    N. Kirschner, R. Rosenthal, M. Furuse, I. Moll, M. Fromm, JM. Brandner,
    University Hospital Hamburg-Eppendorf, Germany.

  • Penetration of topical clobetasol into human skin ex vivo: skin impedance supports dermal Open Flow Microperfusion (dOFM),
    S. Schwingenschuh
    , K. Tiffner, C. Dragatin, T. Dutkur , C. Höfferer, M. Hajnsek, R. Raml, A. Mautner, M. Bodenlenz, T.R. Pieber, F. Sinner,
    Medical University Graz, Austria.

  • Alterations in the regulatory T cell population in atopic-dermatitis-like cutaneous inflammation in mice,
    V. Martinz,
    CH. Tripp, D. Finke, R. Gruber, CH.-Tiefenthaler, M. Schmuth, S. Dubrac,
    Innsbruck Medical University, Austria.

  • Deregulated retinoid signalling in skin of mice during atopic sensitization are mediated via RAR and PPARδ pathways,
    J. Gericke, J. Ittensohn, D. Töröcsik, A.l deLera, R. Rühl,
    University of Debrecen, Hungary & Vigo, Spain.

10:30 - 11:00 General assembly of E2BRN


  • P1. Genotype-phenotype correlations of connexion 26 epidermal skin disorders reveal differential sensitivity to skin microflora,
    S. Donnelly, S. Lang, M.A.M. van Steensel, P.E. Martin,
    Glasgow , UK & Maastricht, The Netherlands

  • P2. Atopic eczema patients show a decreased ceramide chain length that associates with a decreased barrier function,
    J. van Smeden, M. Janssens, R.J. Vreeken, S. Kezic, A.P.M. Lavrijsen, J.A. Bouwstra,
    Leiden & Amsterdam, The Netherlands.

  • P3. Analysis of protein-protein interaction between late cornified envelope proteins and corneodesmosin,
    Bergboer, MG. Dulak, IMJJ. van Vlijmen-Willems, N. Jonca, PLJM. Zeeuwen, J. Schalkwijk, Nijmegen,
    The Netherlands & Toulouse, France.

  • P4. Assessment of murine epidermal calcium distribution via 2-photon fluorescence lifetime imaging microscopy (2P-FLIM) in eczema and native skin,
    C. Börnchen
    , EM. Peters, V. Failla, MJ. Behne, I. Moll, JM. Brandner,
    Hamburg & Giessen, Germany.

  • P5. TMEM45A gene expression is correlated with late differentiation in human normal epidermal keratinocytes,
    A. Hayez
    , A. Sekulic, M. Reynier, E. Roegiers, C. Michiels, Y. Poumay,
    Namur, Belgium.

  • P6. Xanthine derivatives activate filaggrin deimination,
    MC. Méchin
    , MF. Galliano, S. Daunes-Marion, S. Poigny, JL. Vidaluc, S. Bessou-Touya, H. Duplan, G. Serre, M. Simon,
    CNRS; INSERM; Pierre Fabre Labs. & University of Toulouse, France.

  • P7. Arylhydrocarbon receptor activation promotes epidermal barrier formation and attenuates Th2-cytokine dependent inflammatory processes: The biological basis of coal tar therapy in atopic dermatitis,
    EH. van den Bogaard
    , JGM. Bergboer, AMG. Bergers-Vonk, IMJJ. van Vlijmen-Willems, SV. Hato, P. van der Valk, J-M. Schröder, I. Joosten, PLJM. Zeeuwen, J. Schalkwijk,
    Nijmegen, The Netherlans & Kiel, Germany.

  • P8. Skin penetration and action of topical clobetasol in lesional and uninvolved skin in psoriatic patients by dermal Open Flow Microperfusion (dOFM),
    N. Wagner, M. Bodenlenz, K. Benkali, T. Pieber, R. Raml, C. Dragatin, P. Martel, F. Rony, F. Sinner,
    Galderma R&D, Sophia Antipolis, France & Medical University Graz, Austria.

  • P9. Increased FADS2-derived n6-PUFAs and reduced n3-PUFAs in serum of atopic dermatitis patients
    J. Mihaly
    , T. Marosvölgyi, A. Szegedi, D. Törőcsik, T. Decsi, R. Rühl,
    University of Debrecen, Hungary.

  • P10. Ultrastructural evaluation of the stratum corneum in peeling skin disease suggests a compensatory tight junction upregulation
    M. Haftek
    , S. Callejon, F. Pirot, H.Traube, V. Oji,
    University of Lyon 1, France & University of Münster, Germany.

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