12th Meeting

of the

European Epidermal Barrier Research Network

(E2BRN)

10-11 September, 2014

Copenhagen (Denmark)


Scientific Organising Committee:
Nathalie Jonca (Toulouse, France) and Edith Hummler (Lausanne, Switzerland)


Correspondence:
Nathalie Jonca and Edith Hummler


Website: E2BRN


Location: Tivoli Hotel and Congress Center, Room Lumbye

 


Program of the E2BRN meeting - pdf (130 kb) last update: September, 5th, 2014

Scientific Program

Wednesday, September 10,2014

09:00 - 10:35

Session 1
(Topic: Barrier function and ichthyosis pathophysiology)

Chairs: tbd

09:00 - 09:25
Keynote lecture 1:
David Kelsell (London, UK)
Disease gene discovery: key protease functions in the epithelial barrier
(20 min + 5 min discussion)
09:25 - 09:50

Keynote lecture 2:
Claus-Werner Franzke (Freiburg, Germany)
The ADAM17/EGFR signaling axis as modulator of the skin barrier homeostasis
(20 min + 5 min discussion)
09:50 - 10:05

Matthias Schäfer (Zürich, Switzerland)
Activation of the transcription factor Nrf2 in the murine skin causes chloracne (MADISH)-like skin disease
(12 min + 3 min discussion)
10:05 - 10:20

P. Bland (London, UK)
The up regulation of ABCA1 by the activation of LXRβ and PPARδ/γ to renew archetypical differentiation in Harlequin Ichthyosis
(12 min + 3 min discussion)
10:20 - 10:35

Signe Bek (Odense, Denmark)
Impaired epidermal barrier function compromises SREBP-mediated lipogenic gene expression in liver
(12 min + 3 min discussion)

 
10:35 - 11:00

Coffee break

 
11:00 - 12:35

Session 2
(Topic: Microbiome, antimicrobial barrier, proteases and inhibitors)

Chairs: tbd

11:00 - 11:25
Keynote lecture 1:
Joost Schalkwijk, (Nijmegen, The Netherlands)
Dynamics of the skin microbiome: the role of antimicrobial proteins and skin barrier components
(20 min + 5 min discussion)
11:25 - 11:50
Keynote lecture 2:
Leopold Eckhart (Vienna, Austria)
Evolutionary genetics of S100 fused-type proteins
(20 min + 5 min discussion)
11:50 - 12:05
E De Vuyst (Namur, Belgium)
Alterations induced by IL-4, IL-13 and IL-25 in a reconstructed human epidermis are reminiscent of atopic dermatitis
(12 min + 3 min discussion)
12:05 - 12:20
M Bernard (Lyon, France)
IL-1beta promotes atopic dermatitis phenotype in 3D reconstructed normal human epidermis
(12 min + 3 min discussion)
12:20 - 12:35
Katja Bäsler (Hamburg, Germany)
Positive influence of Staphylococcus aureus infection on tight junction functionality
(12 min + 3 min discussion each)
 
12:35 - 13:00
Lunch break
 
13:00 - 14:30 Poster viewing
There will be 2 poster prizes
 
 
Thursday, September 11,2014

08:00 - 10:00 Session 3
(Topic: Adherens junctions and skin homeostasis)

Chairs: tbd

08:00 - 08:25
Keynote lecture 1:
Sarah Küchler (Berlin, Germany)
Impact of filaggrin on skin homeostasis – Results from studies in filaggrin-deficient skin models
(20 min + 5 min discussion)
08:25 - 08:50
Keynote lecture 2:
Carien Nissen (Cologne, Germany)
Classical cadherins in the regulation of epidermal integrity and barrier function
(20 min + 5 min discussion)
08:50 - 09:05
4 Merel A.W. Oortveld (Nijmegen, The Netherlands)
Corneoconnectin: a novel skin-specific protein that interacts with late cornified envelope proteins and is induced upon skin barrier disruption
(12 min + 3 min discussion)
09:05 - 09:20
Christiane Mathes (Saarland, Germany)
Expression and localization of tight junction proteins and tight junction barrier function in porcine hair follicles
(12 min + 3 min discussion)
09:20 - 09:35
Michel Simon (Toulouse, France)
Filaggrin-2 is essential for proper keratinocyte differentiation in a three-dimensional reconstructed human epidermis
(12 min + 3 min discussion)
09:35 - 09:50
V. van Drongelen (Leiden, The Netherlands)
Filaggrin knockdown does not affect stratum corneum barrier properties of a human skin equivalent
(12 min + 3 min discussion)
09:50 - 10:00
Presentation of the new COST network StanDerm
SM John / S Kezic / J Brandner
     
     
Posters    
     
P1   The kinase RIPK1 acts as a guardian of skin homeostasis
Lefebvre S, Takahashi N, Gilbert B, Duprez L, Leurs K, Berger SB, Bertin J, Gough PJ, Vandenabeele P, Declercq W.
Gent, Belgium
P2   Loss of acyl-coA binding protein in mice results in increased inflammation in the skin
Engelsby H, Neess D, Sandhoff R, Færgeman NJ.
Odense, Denmark; Heidelberg, Germany
P3   withdrawn
P4   Alterations in eicosanoid metabolism may impact PPARalpha signaling in a murine model of AD
Blunder S, Rühl R, Radner F, Schmuth M, Dubrac S.
Innsbruck, Austria
P5   PPAR agonists upregulate filaggrin expression and improve lipid composition and organization in a filaggrin knock down skin model
Wallmeyer L, Lehnen D, Sochorova M, Skolova B, Schäefer-Korting M, Vavrova K, Küchler S.
Berlin, Germany; Hradec Kralove, Czech Republic
P6   Silencing of TMEM45A gene in human keratinocytes alters some differentiation markers but does not impede epidermal morphogenesis
Hayez A, Malaisse J, Lambert de Rouvroit C, Michiels C, Poumay Y.
Namur, Belgium
P7   C-terminal filaggrin-2 targets the bacterial replication: a new antimicrobial mode of action?
Hansmann B, Gerstel U, Schröder JM.
Kiel, Germany
P8   Central role of Cldn-1 in lesional but not in non-lesional atopic dermatitis
Gruber R, Börnchen C, Rose K, Daubmann A, Peters EM, Danso M, Bouwstra JA, Hennies HC, Schmuth M, Brandner JM.
Innsbruck, Austria; Hamburg, Giessen, Cologne, Germany; Leiden, The Netherlands
P9   Th2 cytokines induce atopic eczema like characteristics in human skin equivalents
Danso MO, van Drongelen V, Mulder A, van Smeden J, El Ghalbzouri A, Bouwstra JA
Leiden, The Netherlands
P10   Trichohyalin-like proteins have evolutionarily conserved roles in the morphogenesis of skin appendages
Mlitz V, Strasser B, Jaeger K, Hermann M, Ghannadan M, Buchberger M, Alibardi L, Tschachler E, Eckhart L.
Vienna, Austria
P11   Lipid to protein ratio plays an important role in the skin barrier function of atopic eczema patients
van Smeden J, Janssens M, Puppels GJ, Lavrijsen APM, Caspers PJ, Bouwstra JA.
Leiden,Rotterdam, The Netherlands
P12   Meaning of relative gene expression in multilayered cultures of epidermal keratinocytes.
Malaisse J, Hermant M, Hayez A, Poumay Y, Lambert de Rouvroit C.
Namur, Belgium
P13   Development of a perfusion chamber for the cultivation of 3d skin constructs
Strüver K, Gorreja F, Friess W, Küchler S.
Munich, Berlin, Germany
P14   Changes to the Stratum Corneum after narrow-band UVB (311nm) phototherapy in polymorphic light eruption patients
Pond EJ, O’Neill CA, Rhodes LE, Gibbs NK.
Manchester, UK
P15   Ultrastructural analysis of skin substrates used for drug permeation studies.
Abdayem R, Roussel L, Zaman N, Pirot F, Haftek M.

Lyon, France
P16   Model stratum corneum membranes with sphingosine, phytosphingosine and dihydrosphingosine ceramides: Permeability & Biophysics
Skolova B, Janusova B, Tesar O, Jandovska K, Hudska K, Palát K,
Vavrova K.
Hradec Kralove, Czech Republic
P17   Ceramides with Long (C16) and Very Long (C24) Acyls in Model Skin Lipid Membranes: Differences in Permeability and Microstructure
Pullmannová P, Školová B, Hudská K, Kovácik A, Zbytovská J, Vávrová K
Hradec Kralove, Czech Republic
P18   Organic osmolytes increase keratinocyte tight junction barrier function and protein expression
El-Chami C, Haslam I, Steward M, O’Neill C, Manchester, UK
Gentofte, Denmark
P19   Reaction and regeneration to SLS according to filaggrin status and phenotype
Bandier J.
Gentofte, Denmark
P20   Human skin challenged by additives and contaminants migrating from consumer products: Can we trust its barrier function?
Mielke N, Hutzler C, Kappenstein O, Vieth B, Luch A.
Berlin, Germany
P21   Optical methods for measuring diffusion in skin
Dreier J, Brewer J.
Odense, Denmark
P22   Activation of the transcription factor Nrf2 in the murine skin causes chloracne (MADISH)-like skin disease
Schäfer M, Willrodt AH, Kurinna S, Geusau A, Gruber F, Sorg O, Roop D, Sandhoff K, Saurat JH, Tschachler E, Schneider M, Bloch W, Beer HD, Werner S.
Zurich, Geneva, Switzerland; Vienna, Austria; Denver, USA; Bonn, Munich, Cologne, Germany
P23   The up regulation of ABCA1 by the activation of LXRß and PPARd/? to renew archetypical differentiation in Harlequin Ichthyosis
Bland P, Fell B, Kelsell DP.
London, UK
P24   Impaired epidermal barrier function compromises SREBP-mediated lipogenic gene expression in liver
Neess D, Bek S, Bloksgaard M, Marcher A-B, Fargeman N, Mandrup S
Odense, Denmark
P25   Alterations induced by IL-4, IL-13 and IL-25 in a reconstructed human epidermis are reminiscent of atopic dermatitis.
De Vuyst E, Giltaire S, Lambert de Rouvroit C, Chrétien A, Salmon M, Poumay Y., Namur, Les Isnes, Belgium
P26   IL-1beta promotes atopic dermatitis phenotype in 3D reconstructed normal human epidermis.
Bernard M, Guiraud B, Bessou-Touya S, Duplan H, Rozieres A, Goujon C, Nicolas JF, Vocanson M, Galliano MF.
Lyon, Toulouse, France
P27   Positive influence of Staphylococcus aureus infection on TJ functionality
Bäsler K, Galliano MF, Houdek P, Guiraud B, Vidal-y-Sy S, Wladykowski E, Käfer J, Bessou-Touya S, Duplan H, Brandner JM.
Hamburg, Germany, Toulouse, France
P28   Corneoconnectin: a novel skin-specific protein that interacts with late cornified envelope proteins and is induced upon skin barrier disruption
Oortveld MAW, Kersten FF, Eeftens J, Niehues H, van Vlijmen-Willems IMJJ, Zeeuwen PLJM, Schalkwijk J.
Nijmegen, The Netherlands
P29   Expression and localization of tight junction proteins and tight junction barrier function in porcine hair follicles
Mathes C, Brandner JM, Hansen S, Vidal-y-Sy S, Schaefer U, Lehr CM.
Saarbrucken, Hamburg, Germany
P30   Filaggrin-2 is essential for proper keratinocyte differentiation in a three-dimensional reconstructedhuman epidermis.
Pendaries V, Le Lamer M, Cau L, Malaisse J, Hansmann B, Kezic S,
Serre G, Simon M.
Toulouse, France, Namur, Belgium, Amsterdam, Netherlands, Kiel, Germany
P31   Filaggrin knockdown does not affect stratum corneum barrier properties of a human skin equivalent
Van Drongelen V, Danso MO, Bouwstra JA, El Ghalbzouri A.
Leiden, The Netherlands
     
     

E2BRN meeting 2014 is supported by


Gold sponsors:

 


Silver sponsors:

 


 
Greentech



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