European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

Research Focus

  1. Genetic mechanisms in atopic eczema (atopic dermatitis)

  2. Copy number variation in FLG and other genes in the epidermal differentiation complex

  3. Transcriptome analysis of skin

  4. Skin organotypic culture

  5. Clinical translation



Research Focus Picture


Important Publications

  1. Hansjörg Baurecht, Melanie Hotze, Stephan Brand, Carsten Büning, Paul Cormican, Aiden Corvin, David Ellinghaus, Eva Ellinghaus, Jorge Esparza-Gordillo, Regina Fölster-Holst, Andre Franke, Christian Gieger, Norbert Hubner, Thomas Illig, Alan D Irvine, Michael Kabesch, Young AE Lee, Wolfgang Lieb, Ingo Marenholz, WH Irwin McLean, Derek, W Morris, Ulrich Mrowietz, Rajan Nair, Markus M Nöthen, Natalija Novak, Grainne M O’Regan, the PAGE consortium, Stefan Schreiber, Catherine Smith, Konstantin Strauch, Philip E Stuart, Richard Trembath, Lam C Tsoi, Michael Weichenthal, Jonathan Barker, James T Elder, Stephan Weidinger, Heather J Cordell and Sara J Brown.
    Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
    Am J Hum Genet. 2015 Jan 8;96(1):104-20

  2. Simpson EL, Chalmers JR, Hanifin JM, Thomas KS, Cork MJ, McLean WH, Brown SJ, Chen Z, Chen Y, Williams HC.
    Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention
    J Allergy Clin Immunol. 2014 Oct;134(4):818-23

  3. NJ Schurch, C Cole, A Sherstnev, J Song, C Duc, KG Storey, WHI McLean, SJ Brown, GG Simpson, GJ Barton.
    Improved Annotation of 3’ Untranslated Regions and Complex Loci by Combination of Strand-Specific Direct RNA Sequencing, RNA-Seq and ESTs.
    PLoS One. 2014 Apr 10;9(4):e94270

  4. C Cole, K Kroboth, NJ Schurch, A Sandilands, A Sherstnev, GM O’Regan, RM Watson, WHI McLean, GJ Barton, AD Irvine and SJ Brown
    Filaggrin-stratified transcriptome analysis of paediatric skin identifies mechanistic pathways in atopic dermatitis
    J Allergy Clin Immunol 2014; 134(1);82-91

  5. Thawer-Esmail F, Jakasa I, Todd G, Wen Y, Brown SJ, Kroboth K, Campbell LE, O'Regan GM, McLean WH, Irvine AD, Kezic S, Sandilands A.
    South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin
    J Allergy Clin Immunol. 2014 Jan;133(1):280-2

  6. Saunders SP*, Goh CSM* (*joint 1st authors) Brown SJ, Palmer CNA et al.
    Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in humans
    J Allergy Clin Immunol 2013 Nov;132(5):1121-9

  7. Weidinger S, et al, Brown SJ, Cookson WOC, Lathrop GM, Irvine AD and Moffatt MF
    A genome-wide association study of Atopic Dermatitis identifies loci with overlapping effects on asthma and psoriasis
    Human Molecular Genetics 2013 Dec 1;22(23):4841-56

  8. Ellinghaus D, Baurecht H, et al, Brown S, McLean WH, Irvine AD, Schreiber S, Lee YA, Franke A, Weidinger S.
    High-density genotyping study identifies four new susceptibility loci for atopic dermatitis
    Nat Genet. 2013 Jul; 45 (7):808-12

  9. Pöhler E, Zamiri M, Harkins C, Salas-Alanis JC, Perkins W, Smith FJ, Irwin McLean WH, Brown SJ
    Heterozygous mutations in AAGAB cause type 1 punctate palmoplantar keratoderma with evidence for increased growth factor signaling
    J Invest Dermatol. 2013 Dec;133(12):2805-8

  10. Asai Y, Greenwood C, Hull PR, Alizadehfar R, Ben-Shoshan M, Brown SJ, Campbell L, Michel DL, Bussières J, Rousseau F, Fujiwara TM, Morgan K, Irvine AD, McLean WH, Clarke A.
    Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status
    J Allergy Clin Immunol. 2013 Jul;132(1):239-42

  11. Pohler E, et al, McGrath JA, Brown SJ, Goudie DR, Reversade B, Munro CS, McLean WH.
    Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma
    Nat Genet. 2012 Nov;44(11):1272-6

  12. Sandilands A, Brown SJ, Goh CS, Pohler E, Wilson NJ, Campbell LE, Miyamoto K, Kubo A, Irvine AD, Thawer-Esmail F, Munro CS, McLean WH, Kudoh J, Amagai M, Matsui T.
    Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin
    J Invest Dermatol. 2012;132(5):1507-10

  13. Brown SJ, Kroboth K, Sandilands A, Campbell L, Pohler E, Kezic S, Cordell HJ, McLean WHI and Irvine AD.
    Intragenic copy number variation within filaggrin contributes to risk of atopic dermatitis with a dose-dependent effect
    J Invest Dermatol 2012;132(1):98-104

  14. Brown SJ and McLean WHI.
    One remarkable molecule: Filaggrin
    J Invest Dermatol 2012;132(3 Pt 2):751-62

  15. Chen H, Common JE, Haines RL, Balakrishnan A, Brown SJ, Goh CS, Cordell HJ, Sandilands A, Campbell LE, Kroboth K, Irvine AD, Goh DL, Tang MB, Van Bever HP, Giam YC, McLean WH, Lane EB.
    Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations
    Br J Dermatol. 2011; 165(1):106-14

  16. Brown SJ, Asai Y, Cordell HJ, Campbell LE, Zhao Y, Liao H, et al.
    Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy
    J Allergy Clin Immunol 2011; 127(3): 661-667

  17. Common JE, Brown SJ (joint 1st authors), Haines RL, Goh CS, Chen H, Balakrishnan A, Munro CS, Tan AW, Tan HH, Tang MB, Lane EB.
    Filaggrin Null Mutations Are Not a Protective Factor for Acne Vulgaris
    J Invest Dermatol. 2011; 131(6):1378-80

  18. O’Regan GM, Campbell LE, Cordell HJ, Irvine AD, McLean WHI and Brown SJ.
    Chromosome 11q13.5 variant associated with childhood eczema; an effect supplementary to filaggrin mutations
    J Allergy Clin Immunol 2010;125(1):170-4

last update: 2015, March