European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

Research Focus

  1. In vivo confocal Raman microspectroscopy of the skin

  2. Molecular epidermal gradients: water, free amino acids, lipids, topically applied products etc

  3. Molecular characterization of healthy and diseased skin



Research Focus Picture


Important Publications

  1. Pudney P.D.A, Mélot M, Caspers PJ, Pol A. van der, Puppels GJ.
    An in vivo Confocal Raman study of the delivery of trans-retinol to the skin.
    Appl Spectr 61(8), 2007

  2. Wascotte V, Caspers PJ, Sterke J de, Jadoul M, Guy R, Préat V.
    Assessment of the "Skin Reservoir" of Urea by Confocal Raman Microspectroscopy and Reverse Iontophoresis in vivo.
    Pharmaceutical Research DOI 10.1007/s11095-007-9314-42007, 2007

  3. Caspers PJ, Lucassen GW, and Puppels GJ.
    Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin.
    Biophys. J. 85:572-580, 2003

  4. Nijssen A, Bakker Schut TC, Heule F, Caspers PJ, Hayes DP, Neumann M, and Puppels GJ.
    Discriminating basal cell carcinoma from its surrounding tissue by Raman spectroscopy.
    J Invest Dermatol. 119:64-69, 2002

  5. Caspers PJ, Lucassen GW, Carter EA, Bruining HA, and Puppels GJ.
    In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles.
    J Invest Dermatol. 116:434-442, 2001

  6. Caspers PJ, Lucassen GW, Bruining HA, and Puppels GJ.
    Automated depth-scanning confocal Raman microspectrometer for rapid in vivo determination of water concentration profiles in human skin.
    J Raman Spectrosc. 31:813-818, 2000

last update: 2007