European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

Research Focus

  1. Lipid and energy metabolism in atopic dermatitis and ichthyosis vulgaris

  2. Environmental triggers of atopic dermatitis

  3. 3D organotypic cultures generated with patient skin cells

  4. Identification of new therapeutic targets in atopic dermatitis



Important Publications

  1. Leman G, Moosbrugger-Martinz V, Blunder S, Pavel P, Dubrac S. 3D-Organotypic Cultures to Unravel Molecular and Cellular Abnormalities in Atopic Dermatitis and Ichthyosis Vulgaris. Cells. 2019; 8(5). pii: E489

  2. Blunder S, Rühl R, Moosbrugger-Martinz V, Krimmel C, Geisler A, Crumrine D, Elias P, Gruber R, Schmuth M, Dubrac S. Alterations in epidermal eicosanoid metabolism contribute to inflammation and impaired late differentiation in FLG-mutated AD. J Invest Dermatol 2017; 137(3): 706-715

  3. Minzaghi D, Pavel P, Dubrac S. Xenobiotic Receptors and Their Mates in Atopic Dermatitis. Int J Mol Sci. 2019; 20(17). pii: E4234

  4. Blunder S, Kõks S, Kõks G, Reimann E, Hackl H, Gruber R, Moosbrugger-Martinz V, Schmuth M, Dubrac S. Enhanced Expression of Genes Related to Xenobiotic Metabolism in the Skin of Patients with Atopic Dermatitis but Not with Ichthyosis Vulgaris. Invest Dermatol. 2018; 138(1):98-108

  5. Elentner A, Schmuth M, Yannoutsos N, Eichmann TO, Gruber R, Radner FPW, Hermann M, Del Frari B, Dubrac S. Epidermal Overexpression of Xenobiotic Receptor PXR Impairs the Epidermal Barrier and Triggers Th2 Immune Response. J Invest Dermatol. 2018; 138(1):109-120

  6. Moosbrugger-Martinz V, Gruber R, Ladstätter K, Bellutti M, Blunder S, Schmuth M, Dubrac S. Filaggrin null mutations are associated with altered circulating Tregs in atopic dermatitis. J Cell Mol Med. 2019; 23(2):1288-1299

  7. Moosbrugger-Martinz V, Tripp CH, Gruber R, Clausen B, Finke D, Heufler C, Fiegl H, Schmuth M, Dubrac S. Atopic dermatitis induces the expansion of thymus-derived regulatory T cells exhibiting a Th2-like phenotype. J Cell Mol Med 2016; 20(5): 930-8





last update: November 2019