European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

Research Focus

  1. Role of the molecules of the epidermal intercellular matrix in regulation of the epidermal homeostasis and barrier function

  2. Epidermal proteoglycans and their interaction with desmosomes, extracellular lipids, and dendritic cells: applications in wound healing, skin ageing and atopy

  3. Pharmacological regulation of the barrier function



Research Focus Picture


Important Publications

  1. Kirschner N, Haftek M, Niessen Cm, Behne Mj, Furuse M, Moll I, Brandner Jm: CD44 knock-out results in an alteration of tight junction composition and function in keratinocytes. J Invest Dermatol 2011; 131: 932-43 (doi:10.1038/jid.2010.390)

  2. Frateschi S, Camerer E, Crisante G, Rieser S, Membrez M, Charles Rp, Beermann F, Stehle Jc, Breiden B, Sandhoff K, Rotman S, Haftek M, Wilson A, Ryser S, Steinhoff M, Coughlin Sr, Hummler E. Par2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nat Commun 2011; 2: 161; http://www.nature.com/ncomms/journal/v2/n1/full/ncomms1162.html

  3. Haftek M., Callejon S, Sandjeu Y, Padois K, Falson F, Pirot F, Portes P, Demarne F, Jannin V. Compartmentalization of the human stratum corneum by persistent tight junction -like structures. Exp Dermatol 2011; 20: 617-21 (doi: 10.1111/j.1600-0625.2011.01315.x)

  4. Haftek M, Simon M and Serre G. Corneodesmosomes: pivotal actors in the stratum corneum cohesion and desquamation. In: " Skin Barrier " (Elias PM, Feingold KR, eds ), Taylor & Francis Group, New York, NY, 2005

  5. Norgett EE, Wolf F, Balme B, Leigh IM, Perrot H, Kelsell DP, and Haftek M. Hereditary " white nails ": a genetic and structural study. Br. J. Dermatol. 151:65-72, 2004

  6. McMillan J, Haftek M, Akiyama M, South AP, McGrath JA, Perrot H, Eady RAJ, and Shimizu H. Alternations in desmosome size and number coincide with the loss of keratinocyte cohesion in skin with homozygous and heterozygous defects in the desmosomal protein plakophilin 1. J Invest Dermatol 121:1-8, 2003

  7. Simon M, Jonca N, Guerrin M, Haftek M, Bernard D, Caubet C, Egelrud T, Schmidt R, and Serre G. Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis, and its relationship to desquamation. J. Biol. Chem., 276: 20292-9, 2001 (+ correction in JBC 276: 47742, 2001)

last update: 2012, June