European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

Research Focus

  1. Role of Dermokine β and γ in the late stages of epidermis differentiation

  2. Corneodesmosin and cohesion of the stratum corneum: involvement in pathophysiology

  3. Study of the cornified envelope and its component LCE6A



Research Focus Picture


Important Publications

  1. Mazereeuw-Hautier J, Leclerc EA, Simon M, Serre G, Jonca N. A novel mutation in CDSN causes peeling skin disease in a patient from Morocco. Br J Dermatol in press

  2. Leclerc EA, Gazeilles L, Serre G, Guerrin M, Jonca N. The ubiquitous dermokine delta activates Rab5 in the early endocytic pathway. PloS One, 6:e17816, 2011

  3. Jonca N, Caubet C, Leclerc EA, Guerrin M, Simon M, Serre G. Protease sensitivity of corneodesmosin variants encoded by the six more common CDSN haplotypes. J Invest Dermatol 131:1381-1384, 2011

  4. Leclerc EA, Huchenq A, Mattiuzzo NR, Metzger D, Chambon P, Ghyselinck N, Serre G, Jonca N, Guerrin M. Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction. J Cell Sci 122:2699-2709, 2009

  5. Toulza E, Mattiuzzo N, Galliano M-F, Jonca N, Dossat C, Jacob D, De Daruvar A, Wincker P, Serre G, Guerrin M. Large scale identification of human genes implicated in epidermal barrier function. Genome biology 8:R107:1-23, 2007

  6. Toulza E, Galliano M-F, Jonca N, Gallinaro H, Méchin M-C, Ishida-Yamamoto A, Serre G, Guerrin M. The human dermokine gene: description of novel isoforms with different tissue-specific expression and subcellular location. J Invest Dermatol 126:503-506, 2006

  7. Caubet C, Jonca N, Brattsand M, Guerrin M, Bernard D, Schmidt R, Egelrud T, Simon M, Serre G. Degradation of corneodesmosome components by two kallikreins SCTE/KLK5/hK5 and SCCE/KLK7/hK7. J Invest Dermatol 122:1235-1244, 2004

  8. Caubet C, Jonca N, Lopez F, Estève J-P, Simon M, Serre G. Homo-oligomerisation of human corneodesmosin is mediated by its N-terminal glycine loop domain. J Invest Dermatol 122:747-754, 2004

  9. Levy-Nissenbaum E, Betz R-C, Frydman M, Simon M, Lahat H, Bakhan T, Goldman B, Bygum A, Pierick M, Hillmer A-M, Jonca N, Toribio J, Kruse R, Dewald G, Cichon S, Kubisch C, Guerrin M, Serre G, Nöthen M-M, Pras E. Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin. Nat Genet 34:151-153, 2003

  10. Jonca N, Guerrin M, Hadjiolova K, Caubet C, Gallinaro H, Simon M, Serre G. Corneodesmosin, a component of epidermal corneocyte desmosomes, displays homophilic adhesive properties. J Biol Chem 277:5024-5029, 2002

last update: 2011, September