European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

Research Focus

  1. Stratum corneum lipid biophysics – characterization of inter and intra-molecular organization in in vivo and ex vivo stratum corneum and in vitro barrier lipid models

  2. Vibrational spectroscopy and imaging applied to skin biology and topical delivery of exogenous molecules

  3. Dermal and transdermal drug delivery

  4. Interactions between topical formulations, their molecular components, and the outer epidermis



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Important Publications

  1. Yang, T. C. Moore, C. R. Iacovella, M. Thompson, D. J. Moore, and C. McCabe,
    “Examining Tail and Headgroup Effects on Binary and Ternary Gel-Phase Lipid Bilayer Structure,”
    J. Phys. Chem. B, vol. 124, no. 15, pp. 3043–3053, Mar. 2020, doi: 10.1021/acs.jpcb.0c00490.

  2. M. Gorcea, M. E. Lane, and D. J. Moore,
    “A proof-of-principle study comparing barrier function and cell morphology in face and body skin,”
    Int. J. Cosmet. Sci., vol. 41, no. 6, 2019, doi: 10.1111/ics.12568.

  3. G. S. Gooris, M. Kamran, A. Kros, D. J. Moore, and J. A. Bouwstra,
    “Interactions of dipalmitoylphosphatidylcholine with ceramide-based mixtures,”
    Biochim. Biophys. Acta - Biomembr., vol. 1860, no. 6, 2018, doi: 10.1016/j.bbamem.2018.02.024.

  4. T. Haque, M. E. Lane, B. C. Sil, J. M. Crowther, and D. J. Moore,
    “In vitro permeation and disposition of niacinamide in silicone and porcine skin of skin barrier-mimetic formulations,”
    Int. J. Pharm., vol. 520, no. 1–2, 2017, doi: 10.1016/j.ijpharm.2017.01.054.

  5. P. A. Bulsara, P. Varlashkin, J. Dickens, D. J. Moore, A. V. Rawlings, and M. J. Clarke,
    “The rational design of biomimetic skin barrier lipid formulations using biophysical methods,”
    Int. J. Cosmet. Sci., vol. 39, no. 2, pp. 206–216, 2017, doi: 10.1111/ics.12366.

  6. R. Hartkamp et al.,
    “Structural properties of phospholipid-based bilayers with long-chain alcohol molecules in the gel phase,”
    J. Phys. Chem. B, vol. 120, no. 50, 2016, doi: 10.1021/acs.jpcb.6b10192.

  7. R. Flach and D. J. Moore,
    “Infrared and Raman imaging spectroscopy of ex vivo skin,”
    Int. J. Cosmet. Sci., vol. 35, no. 2, 2013, doi: 10.1111/ics.12020.

  8. K. Levi, A. Kwan, A. S. Rhines, M. Gorcea, D. J. Moore, and R. H. Dauskardt,
    “Effect of glycerin on drying stresses in human stratum corneum,”
    J. Dermatol. Sci., vol. 61, no. 2, 2011, doi: 10.1016/j.jdermsci.2010.11.011.

  9. G. Zhang, D. J. Moore, C. R. Flach, and R. Mendelsohn,
    “Vibrational microscopy and imaging of skin: From single cells to intact tissue,”
    Anal. Bioanal. Chem., vol. 387, no. 5, 2007, doi: 10.1007/s00216-006-0852-0

  10. G. Zhang, D. J. Moore, K. B. Sloan, C. R. Flach, and R. Mendelsohn,
    “Imaging the prodrug-to-drug transformation of a 5-fluorouracil derivative in skin by confocal Raman microscopy,”
    J. Invest. Dermatol., vol. 127, no. 5, pp. 1205–1209, 2007, doi: 10.1038/sj.jid.5700690

  11. G. Zhang, D. J. Moore, R. Mendelsohn, and C. R. Flach,
    “Vibrational microspectroscopy and imaging of molecular composition and structure during human corneocyte maturation,”
    J. Invest. Dermatol., vol. 126, no. 5, 2006, doi: 10.1038/sj.jid.5700225.

last update: May 2020