European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

Research Focus

  1. The role of adherens junctions and polarity proteins in epidermal barrier formation and function



Research Focus Picture


Important Publications

  1. Billion K*, Ibrahim H*, Mauch C, and Niessen CM. Increased soluble E-cadherin in melanoma patients, Skin Pharm. Phys., in press

  2. Tunggal JA*, Helfrich I, * Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T and Niessen CM. E-cadherin is essential for in vivo skin barrier function by regulating tight junctions. EMBO J. 24:1146-1156, 2005

  3. Gottardi CJ*, Niessen CM* and Gumbiner BM. The Adherens Junction. Chapter 8. In: Cell Adhesion, ed. by M. Beckerle, The Frontiers in Molecular Biology series, eds. B.D. Hames and Glover, D.M., Oxford University Press, 2002

  4. Niessen CM and Gumbiner BM. Cadherin mediated cell sorting not determined by adhesion or binding specificity. J. Cell Biol. 156:389-399, 2002

  5. Yap AS*, Niessen CM* and Gumbiner BM. The juxtamembrane of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J. Cell Biol. 141:779-789, 1998

  6. Niessen CM, Hulsman EHM, Oomen LCJM, Kuikman I and Sonnenberg A. A minimal region on the integrin ?beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells. J. Cell Sci. 110:1705-1716, 1997 *co-first authors

last update: 2007, March