European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

Research Focus

  1. Modelling non-tumoral epidermal pathologies in vitro: inflammatory, genetic and infectious diseases

  2. Epidermal morphogenesis and senescence keratinocytes

  3. Cell and tissue response in reconstructed human epidermis after application of irritant or sensitizer chemicals



Research Focus Picture


Important Publications

  1. Hayez, A., Malaisse, J., Roegiers, E., Reynier, M., Renard, C., Haftek, M., Geenen, V., Serre, G., Simon, M., Lambert de Rouvroit, C., Michiels, C. & Poumay, Y. (2014) High TMEM45A expression is correlated to epidermal keratinization. Exp. Dermatol. 23, 339-344. DOI: 10.1111/exd.12403

  2. Malaisse, J., Bourguignon, V., De Vuyst, E., Lambert de Rouvroit, C., Nikkels, A.F., Flamion, B. & Poumay, Y. (2014) Hyaluronan metabolism in human keratinocytes and atopic dermatitis skin is driven by a balance of hyaluronan synthases 1 and 3. J. Invest. Dermatol. Published online. Doi: 10.1038/jid.2014.147

  3. Lambert de Rouvroit, C., Charlier, C., Lederer, D., De Glas, V., De Vuyst, E., Dargent, J.L., Grammatico, P., Binni, F., Rousseau, C., Hennecker, J.L., Nikkels, A.F. & Poumay, Y. (2013) In vitro reconstruction of epidermis from primary Darier’s disease keratinocytes replicates the histopathological phenotype. J. Dermatol. Sci. 71, 138-140. doi:10.1016/j.jdermsci.2013.04.016

  4. Flamant, L., Roegiers, E., Pierre, M., Hayez, A., Sterpin, C., De Backer, O., Arnould, T., Poumay, Y. & Michiels, C. (2012) TMEM45A as a new biomarker of chemoresistance in cancer cells. BMC Cancer 12:391. doi: 10.1186/1471-2407-12-391

  5. Frankart, A., Malaisse, J., Minner, F., De Vuyst, E., Lambert de Rouvroit, C. & Poumay, Y. (2012) Epidermal morphogenesis during progressive in vitro 3D reconstruction at the air-liquid interface. Exp. Dermatol. 21, 871-875. DOI:10.1111/exd.12020

  6. Frankart, A., Coquette, A., Schröder, K.R. & Poumay, Y. (2012) EGF receptor signalling is induced by sensitizing chemicals in keratinocytes of reconstructed human epidermis and regulates the release of interleukin-8.Arch. Dermatol. Res. 304, 289-303. DOI: 10.1007/s00403-012-1209-5

  7. Giltaire, S., Lambert, S. & Poumay, Y. (2011) HB-EGF synthesis and release induced by cholesterol depletion of human epidermal keratinocytes is controlled by extracellular ATP. J. Cell. Physiol. 226, 1651-1659. DOI: 10.1002/jcp.22496

  8. Mathay, C., Pierre, M., Pittelkow, M.R., Depiereux, E., Nikkels, A.F., Colige, A. & Poumay, Y. (2011) Transcriptional profiling after lipid raft disruption in keratinocytes identifies critical mediators of atopic dermatitis pathways. J. Invest. Dermatol. 131, 46-58. doi:10.1038/jid.2010.272

  9. Mathay, C. & Poumay, Y. (2010) Lipid rafts and the oxidative stress hypothesis. J. Invest. Dermatol. 130, 1457-1459. doi:10.1038/jid.2009.425

  10. Minner, F. & Poumay, Y. (2009) Candidate house-keeping genes require evaluation before their selection for studies of human epidermal keratinocytes. J. Invest. Dermatol, 129, 770-773. doi:10.1038/jid.2008.247

  11. Giltaire, S., Herphelin, F., Hérin, M., Stoppie, P. & Poumay, Y. (2009) The CYP26 inhibitor R115866 potentiates the effects of all-trans-retinoic acid on cultured human epidermal keratinocytes. Br. J. Dermatol., 160, 505-513. doi 10.1111/j.1365-2133.2008.08960.x

  12. Mathay, C., Giltaire, S, Minner, F., Bera, E., Hérin, M. & Poumay, Y. (2008) Heparin-binding EGF-like growth factor is induced by disruption of lipid rafts and oxidative stress in keratinocytes and participates in the epidermal response to cutaneous wounds. J. Invest. Dermatol., 128(3), 717-727. doi:10.1038/sj.jid.5701069

  13. Lambert, S., Ameels, H., Gniadecki, R., Hérin, M. & Poumay, Y. (2008) Internalization of EGF receptor following lipid rafts disruption in keratinocytes is delayed and dependent on p38 MAPK activation. J. Cell. Physiol., 217, 834-845. DOI: 10.1002/jcp.21563

  14. Poumay, Y. & Coquette, A. (2007) Modelling the human epidermis in vitro: tools for basic and applied research. Arch. Dermatol. Res. 298, 361-369. DOI:10.1007/s00403-006-0709-6

  15. Poumay, Y., Dupont, F., Marcoux, S., Leclercq-Smekens, M., Hérin, M. & Coquette, A. (2004) A simple reconstructed human epidermis : preparation of the culture model and utilization in in vitro studies. Arch. Dermatol. Res. 296, 203-211. DOI 10.1007/s00403-004-0507-y

  16. Jans, R., Atanasova, G., Jadot, M. & Poumay, Y. (2004) Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38. J. Invest. Dermatol. 123, 564-573. DOI : 10.1111/j.0022-202x.2004.23221.x

  17. Jans, R., Sartor, M., Jadot, M. & Poumay, Y. (2004) Calcium entry into keratinocytes induces exocytosis of lysosomes. Arch. Dermatol. Res. 296, 30-41. DOI: 10.1007/s00403-004-0469-0

  18. Coquette, A., Berna, N., Vandenbosch, A., Rosdy, M., De Wever, B., & Poumay, Y. (2003) Analysis of the induction and release of interleukin-1a (IL-1a) and interleukin-8 (IL-8) in in vitro reconstructed human epidermis in order to predict in vivo skin irritation and/or sensitisation. Toxicology In Vitro 17, 311-321

  19. De Potter, I.Y., Poumay, Y., Squillace, K. & Pittelkow, M.R. (2001) Human EGF Receptor (HER) family and Heregulins members are differentially expressed in epidermal keratinocytes and modulate differentiation. Exp. Cell Res. 271, 315-328

  20. Smits, P., Poumay, Y., Tylzanowski, P., Karperien, M., Wouters, J., Ponec, M., Huylabroeck, D. & Merregaert, J. (2000) Differentiation-dependent alternative splicing and expression of the Extracellular Matrix Protein 1 (Ecm1) gene in human keratinocytes. J. Invest. Dermatol. 114, 718-724

  21. Baudoux, B., Castanares-Zapatero, D., Leclercq-Smekens, M, Berna, N.. & Poumay, Y. (2000) The tetraspanin CD9 associates with the integrin a6b4 in cultured human epidermal keratinocytes and is involved in cell motility. Eur. J. Cell Biol. 79, 41-51

last update: 2014, May