European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

Research Focus

  1. Epidermal Clinical: skin pathology, occupational and environmental dermatology, genodermatosis, wound healing, irritant and allergic contact dermatitis, atopic dermatitis, dry skin and aged skin, skin care

  2. Basic research: barrier function of the skin, lipids (in particular ceramids and fatty acids) in skin barrier function, epidermal differentiation in skin barrier function, eczema and psoriasis, cytokines in skin barrier function and wound healing
    adhesion molecules in skin barrier function and wound healing, antimicrobial defense of the skin, skin pharmacology and toxicology, role of urea in eczema, psoriasis and dry skin, lipids and skin barrier function in eczema and psoriasis



Research Focus Picture


Important Publications

  1. Jensen JM, Forl M, Winoto-Morbach S, Seite S, Schunck M, Proksch E, and Schutze S. Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging. Exp. Dermatol. 14:609-18, 2005

  2. Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, and Saftig P. ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration and beta-catenin translocation. Proc. Natl. Acad. Sci. (USA) 102:9182-7, 2005

  3. Proksch E, and Lachapelle JM. The management of dry skin with topical emollients - recent perspectives. J. Dtsch. Dermatol. Ges. 3:768-774, 2005

  4. Egberts F, Heinrich M, Jensen JM, Winoto-Morbach S, Pfeiffer S , Wickel M, Schunck M, Steude J, Saftig P, Proksch E, and Schütze S. Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation. J. Cell Sci. 117: 2295-2307, 2004

  5. Wang XP, Schunck M, Kallen KJ, Trautwein C, Rose-John S, and Proksch E. The Interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. J. Invest. Dermatol. 123:124-31, 2004

  6. Jensen JM, Fölster-Holst R, Baranowsky A , Schunck M, Neumann C, Schütze S and Proksch E. Impaired Sphingomyelinase Activity and Epidermal Differentiation in Atopic Dermatitis. J. Invest. Dermatol. 122:1423-1431, 2004

last update: 2006, May