European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

Research Focus

  1. Drug delivery systems for topical application, dermal and transdermal delivery

  2. Animal models of cutaneous inflammation, infection and wound healing

  3. Topical delivery of antioxidants

  4. Chemoprevention of skin photocarcinogenesis



e2brn - Research Focus Picture


Important Publications

  1. Ascenso A, Pedrosa T, Pinho S, Pinho F, Ferreira de Oliveira JMP, Marques HC, Oliveira H, Simões S, Santos C (2015) The effect of lycopene pre-exposure on UV-B irradiated human keratinocytes. Oxid Med Cell Longev. Research Article 903961. In press

  2. Ascenso A, Raposo S, Batista C, Cardoso P, Mendes T, Praça FG, Bentley MVLB, Simões S (2015) Development characterization and skin delivery studies of related ultradeformable vesicles transfersomes ethosomes and transethosomes. Int J Nanomed 10:5837-5851

  3. Santos JM, Camões SP, Filipe E, Cipriano M, Barcia RN, Filipe M, Teixeira M, Simões S, Gaspar M, Mosqueira D, Nascimento DS, Pinto-do-Ó P, Cruz P, Cruz H, Castro M, Miranda JP (2015) Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing. Stem Cell Res Ther. 6:90

  4. Menezes AC, Raposo S, Simões S, Ribeiro H, Oliveira H, Ascenso A (2015) Prevention of photocarcinogenesis by agonists of 5-HT1A and antagonists of 5-HT2A receptors. Mol Neurobiol. Jan 15. DOI: 10.1007/s12035-014-9068-

  5. Raposo S, Tavares R, Gonçalves L, Simões S, Urbano M, Ribeiro HM (2015) Mometasone-furoate – loaded cold processed oil-in-water emulsions: in vitro and in vivo studies. Drug Deliv. 22:562-572

  6. Marto J, Baltazar D, Duarte A, Fernandes A, Gouveia L, Militão M, Salgado A, Simões S, Oliveira E, Ribeiro HM (2015) Topical gels of etofenamate: in vitro and in vivo evaluation. Pharm Dev Technol. 20:710-715

  7. Ascenso A, Ribeiro H; Marques H, Oliveira H, Santos C, Simões S (2014) Chemoprevention of photocarcinogenesis by lycopene. Exp Dermatol. 23:874-878

  8. Ascenso A, Salgado A, Euletério C, Praça FG, Bentley MVLB, Marques HC, Oliveira H, Santos C, Simões S (2014) In vitro and in vivo topical delivery studies of tretinoin - loaded ultradeformable vesicles. Eur J Pharm Biopharm. 88:48-55

  9. Ascenso A, Pinho S, Euletério C, Praça FG , Bentley MVLB, Oliveira H, Santos C, Silva O, Simões S (2013) Lycopene from Tomatoes: Vesicular nanocarrier formulations for dermal delivery. J Agric Food Chem. 61:7284-7293

  10. Raposo S, Simões S, Almeida AJ, Ribeiro H (2013) Advanced vehicles for topical delivery of glucocorticoids. Expert Opin Drug Del. 10:857-77

  11. Simões S, Marques C, Cruz ME, Martins MBF (2009) Anti-inflammatory effects of locally applied enzyme-loaded ultradeformable vesicles on an acute cutaneous model. J Microencapsul. 26:649–658.

  12. Simões SI, Delgado TC, Lopes RM, Jesus S, Ferreira AA, Morais JA, Cruz ME, Corvo ML, Martins MB (2005) Developments in the rat adjuvant arthritis model and its use in therapeutic evaluation of novel non-invasive treatment by SOD in Transfersomes. J Control Release. 2005 103:419-434

last update: 2015, October