European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

European Epidermal Barrier Research Network

Research Focus

  1. Skin barrier lipids (synthesis and investigation of the relationships between ceramide structure and their skin barrier properties and lipid membrane biophysics to lay the design criteria for a more rational development of ceramide analogs for a prospective use in therapy of skin diseases)

  2. Transdermal permeation enhancers (design and synthesis of novel chemical enhancers with high activity, low toxicity and reversible action, study of their mechanisms of action)

  3. Transdermal drug delivery (using permeation enhancers)



e2brn - Research Focus Picture


Important Publications

  1. Janusova B, Zbytovska J, Lorenc P, Vavrysova H, Palat K, Hrabalek A, Vavrova K. Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 2011; 1811(3):129-137

  2. Novotny M, Klimentova J, Janusova B, Palat K. Hrabalek A, Vavrova K. Ammonium carbamates as highly active transdermal permeation enhancers with a dual mechanism of action. J. Control. Release 2011; 150(2):164-70

  3. Vavrova K, Kovarikova P, Skolova B, Libalova M, Roh J, Cap R, Holy A, Hrabalek A. Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr PMEDAP. Pharm. Res. 2011; 28(12):3105-3115

  4. Novotny J, Hrabalek A, Vavrova K. Synthesis and Structure-Activity Relationships of Skin Ceramides. Curr. Med. Chem. 2010; 17(21):2301-24

  5. Novotny J, Pospechova K, Hrabalek A, Cap R, Vavrova K. Synthesis of Fluorescent C24-Ceramide: Evidence for Acyl Chain Length Dependent Differences in Penetration of Exogenous NBD-Ceramides into Human Skin. Bioorg. Med. Chem. Lett. 2009; 19(24): 6975-6977

  6. Novotny J, Janusova B, Novotny M, Hrabalek A, Vavrova K. Short-Chain Ceramides Decrease Skin Barrier Properties. Skin Pharmacol. Physiol. 2009; 22(1):22-30

  7. Novotny J, Kovarikova P, Novotny M, Janusova B, Hrabalek A, Vavrova K. Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination. Pharm. Res. 2009;26(4):811-21

  8. Vavrova K, Lorencova K, Novotny J, Holy A, Hrabalek A. Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir; influence of pH, ion-pairing and skin species. Eur. J. Pharm. Biopharm. 2008; 70(3):901-7

  9. Vavrova K, Lorencova K, Klimentova J, Novotny J, Holy A, Hrabalek A. Transdermal and dermal delivery of adefovir; effects of pH and permeation enhancers. Eur. J. Pharm. Biopharm. 2008; 69(2):597-604

  10. Vavrova K, Hrabalek A, Mac-Mary S, Humbert P, Muret P. Ceramide analogue 14S24 selectively recovers perturbed human skin barrier. Brit. J. Dermatol. 2007; 157 (4):704-712

  11. Hrabalek A, Dolezal P, Vavrova K, Zbytovska J, Holas T, Klimentova J, Novotny J. Synthesis and Enhancing Effect of Transkarbam 12 on the Transdermal Delivery of Theophylline, Clotrimazole, Flobufen, and Griseofulvin. Pharm. Res. 2006; 23(5):912-8

  12. Vavrova K, Zbytovska J, Hrabalek A. Amphiphilic transdermal permeation enhancers: structure-activity relationships. Curr. Med. Chem. 2005; 12(19):2273-91

last update: 2012, March